Analytical Methods and Advances (AMA) 1

This week I read an article titled "NIR II Light-Response Au Nanoframes: Amplification of a Pressure- and Temperature-Sensing Strategy for Portable Detection and Photothermal Therapy of Cancer Cells". 

(A) Schematic Illustration of the Synthesis of Au NFs and (B) Schematic Diagram of the Construction of the Pressure-Based and Temperature-Based Detection Platforms

In the paper, the authors were trying to make portable device with increased sensitivity and detectability for cancerous cells, as this would foster early diagnosis and swift prognosis (Perfézou et al., 2012, Chinen et al., 2015).

Although previous methods have been used of late including those associated with electrochemical (Cao et al., 2019), fluorescent (Li et al., 2018), microfluidic (Tavakoli et al., 2019), and colorimetric (Hong et al., 2016) measurements. The limitations according to the authors include but are not limited to high cost and difficulty in operation.

The authors synthesized folic acid-conjugated gold nanoframes with amplified pressure and temperature signals" (Liu et al., 2021) in developing the device.

In summary, the device has an excellent sensing performance for the detection of cancers in human blood. Apart from this, the gold nanoframes could kill cancer cells while minimizing the dearth of oxygen in tumors by catalyzing hydrogen peroxide to yield oxygen (Liu et al., 2021). 

If this interests you, you can retrieve the full paper here.

References

Cao, Y.; Dai, Y.; Chen, H.; Tang, Y.; Chen, X.; Wang, Y.; Zhao, J.; Zhu, X. Integration of fluorescence imaging and electrochemical biosensing for both qualitative location and quantitative detection of cancer cells. Biosens. Bioelectron. 2019, 130, 132– 138,  DOI: 10.1016/j.bios.2019.01.024

Chinen, A. B.; Guan, C. M.; Ferrer, J. R.; Barnaby, S. N.; Merkel, T. J.; Mirkin, C. A. Nanoparticle probes for the detection of cancer biomarkers, cells, and tissues by fluorescence. Chem. Rev. 2015, 115, 10530– 10574,  DOI: 10.1021/acs.chemrev.5b00321

Hong, W.; Lee, S.; Chang, H. J.; Lee, E. S.; Cho, Y. Multifunctional magnetic nanowires: A novel breakthrough for ultrasensitive detection and isolation of rare cancer cells from non-metastatic early breast cancer patients using small volumes of blood. Biomaterials 2016, 106, 78– 86,  DOI: 10.1016/j.biomaterials.2016.08.020

Li, Z.; Wang, G. L.; Shen, Y.; Guo, N. N.; Ma, N. DNA-templated magnetic nanoparticle-quantum dot polymers for ultrasensitive capture and detection of circulating tumor cells. Adv. Funct. Mater. 2018, 28, 1707152  DOI: 10.1002/adfm.201707152

Liu, S.; Lu, S.; Sun, S.; Hai, J.; Meng, G.;  Wang, B. NIR II Light-Response Au Nanoframes: Amplification of a Pressure- and Temperature-Sensing Strategy for Portable Detection and Photothermal Therapy of Cancer Cells. Analytical Chemistry 2021 93 (42), 14307-14316, DOI: 10.1021/acs.analchem.1c03486

Perfézou, M.; Turner, A.; Merkoci, A. Cancer detection using nanoparticle-based sensors. Chem. Soc. Rev. 2012, 41, 2606– 2622,  DOI: 10.1039/C1CS15134G

Tavakoli, H.; Zhou, W.; Ma, L.; Perez, S.; Ibarra, A.; Xu, F.; Zhan, S.; Li, X. Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy. TrAC, Trends Anal. Chem. 2019, 117, 13– 26,  DOI: 10.1016/j.trac.2019.05.010